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Landmark Study Defines Normal Ranges for Testosterone Levels

Male hypogonadism Symptoms & causes
By measuring the total level of testosterone in your body, you can identify any factors that might interfere with sex drive (libido), bone mass, fat distribution, muscle mass or production of red blood cells and sperm. At this time, it is unclear whether TRT increases the risk of prostate cancer or symptoms of benign prostatic hyperplasia. However, based on inconclusive data, the FDA does warn of a possible increased risk of cardiovascular disease. Some of these signs and symptoms can be caused by other factors, including medication side effects, obstructive sleep apnea, thyroid problems, diabetes and depression. It’s also possible that these conditions cause low testosterone levels, so treatment might result in increase of testosterone levels.
Some doctors suggest that monitoring testosterone levels every five years, starting at age 35, is a reasonable strategy to follow. If the testosterone level falls too low or if the individual has the signs and symptoms of low testosterone levels described above, testosterone therapy can be considered. Testosterone is considered to be the “male hormone” that’s produced in men by the testes. Sometimes in primary hypogonadism testosterone levels are within the normal range and gonadotropins are high.
Today these evidence-based guidelines statements represent not absolute mandates but provisional proposals for treatment under the specific conditions described in each document. For all these reasons, the guidelines do not pre-empt physician judgment in individual cases. Treating physicians must take into account variations in resources, and patient tolerances, needs, and preferences.
Testosterone undecanoate is typically re-administered at a time point 4 weeks after initial dosing and then every 10 weeks thereafter. As with short-acting IM testosterone injections, the general recommendation is mid-cycle testing, after equilibration, and halfway between the first two 10-week injections. Clinicians should understand that of these agents, only hCG has been approved by the FDA for use in males, specifically to treat males with hypogonadotropic hypogonadism. The overall quantity and quality of studies investigating the use of these alternative agents in males are limited. However, despite these limitations, several studies provide important insights into the impact of SERMs, AIs, and hCG on spermatogenesis. Other population-based studies have attempted to measure prevalence, but have not used standard methodology, which makes arriving at a definitive number of testosterone deficiency difficult.
It’s natural for testosterone levels to vary depending on your age and overall health. If they’re consistently high or low, you may experience unpleasant symptoms worth discussing with your provider. In female adults, high levels of testosterone may be a sign of polycystic ovary syndrome (PCOS).
The original guideline search strategy was updated and used to systematically search PubMed for new evidence published between the previous search end date and February 2022. This search covered the topic areas of all Key Questions listed previously. The literature search returned 11,537 citations after deduplication. During title first pass review, 11,060 citations were excluded. A systematic review utilized research from the Mayo Clinic Evidence Based Practice Center and additional supplementation by the authors. Literature searches included Ovid Medline In-Process & Other Non-Indexed Citations, Ovid MEDLINE, Ovid EMBASE, Ovid Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews, and Scopus. Controlled vocabulary supplemented with keywords was used to search for studies according to each defined question.
All these products require a doctor’s prescription and, except for injections, all are expensive. Explore our Comprehensive Testosterone Test to get a fuller picture of your testosterone status with key components such as sex hormone-binding globulin (SHBG), albumin, total and free testosterone. If you do not notice any change in symptoms after treatment for 3 months, it is less likely that TRT treatment will benefit you.
Our team at The Endocrine Center sees the effects of low testosterone (low T) in men of all ages, and we offer several quick and painless treatments that rebalance their hormones. Here are some of the signs that your testosterone level may have dipped below normal. As men age, testosterone production naturally wanes; in fact, about 40% of men over age 45 have lower levels of turk testosterone — technically called hypogonadism. But if yours is significantly low, your body starts showing signs. Establishing a “normal” level is complex, and measuring testosterone on its own may not be enough to estimate what is the correct level to have in the blood for any one person. Still, research tries to define levels that are healthy, and levels that may be related to disease so patients can be identified and treated.
If you’re experiencing symptoms of low testosterone, such as a decrease in sex drive and hot flashes, talk to a healthcare provider. Late-onset hypogonadism (LOH) is a type of secondary male hypogonadism that results from normal aging. As males age they have a deterioration of hypothalamic-pituitary function and Leydig cell function that decrease testosterone and/or sperm production. For men with low blood testosterone levels and symptoms most likely caused by a low level, the benefits of hormone replacement therapy usually outweigh potential risks. However, for most other men it’s a shared decision with your doctor.